FO-4-15
FO-4-15 is an mGluR1/CaMKIIα activator. FO-4-15 has a protective effect against H2O2 in human neuroblastoma (SH-SY5Y) cells. FO-4-15 can improve cognitive impairment in Alzheimer’s disease mice by activating the mGluR1/CaMKIIα pathway, and can reduce Aβ accumulation, hyperphosphorylated Tau, and synaptic damage[1].
Product Specifications
CAS Number
1030759-58-0
UNSPSC
12352005
Target
CaMK; mGluR; Tau Protein
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=S(N1CCN(CC2=NC(C3=CC=CO3)=NO2)CC1)(C4=CC=C(C)C=C4)=O
Molecular Formula
C18H20N4O4S
Molecular Weight
388.44
References & Citations
[1]Luo ZH, et al. Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3xTg mice by activating the mGluR1/CaMKIIα pathway. Acta Pharmacol Sin. 2024 Aug 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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