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FO-4-15

FO-4-15 is an mGluR1/CaMKIIα activator. FO-4-15 has a protective effect against H2O2 in human neuroblastoma (SH-SY5Y) cells. FO-4-15 can improve cognitive impairment in Alzheimer’s disease mice by activating the mGluR1/CaMKIIα pathway, and can reduce Aβ accumulation, hyperphosphorylated Tau, and synaptic damage[1].

Product Specifications

CAS Number

1030759-58-0

UNSPSC

12352005

Target

CaMK; mGluR; Tau Protein

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=S(N1CCN(CC2=NC(C3=CC=CO3)=NO2)CC1)(C4=CC=C(C)C=C4)=O

Molecular Formula

C18H20N4O4S

Molecular Weight

388.44

References & Citations

[1]Luo ZH, et al. Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3xTg mice by activating the mGluR1/CaMKIIα pathway. Acta Pharmacol Sin. 2024 Aug 16.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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