Pomalidomide-amino-PEG4-NH2 (hydrochloride)

Pomalidomide-amino-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2331259-45-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pomalidomide-amino-peg4-nh2-hydrochloride.html

Purity

99.27

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(COCCOCCOCCOCCN)NC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O.Cl

Molecular Formula

C23H31ClN4O9

Molecular Weight

542.97

Precautions

H302, H315, H319, H335

References & Citations

[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.