(Rac) -Tivantinib
(Rac) -Tivantinib is the isomer of Tivantinib (HY-50686), and can be used as an experimental control. Tivantinib is a highly selective c-Met tyrosine kinase inhibitor with a Ki of 355 nM.
Product Specifications
CAS Number
[1239986-50-5]
Product Name Alternative
(Rac) -ARQ 197; (Rac) -ARQ 198
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-tivantinib.html
Purity
95.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(C1=CN2CCCC3=C2C1=CC=C3)C4C5=CNC6=C5C=CC=C6)NC4=O
Molecular Formula
C23H19N3O2
Molecular Weight
369.42
Precautions
H302, H315, H320, H335
References & Citations
[1]Bai YL, et al. Quantitative analysis of tivantinib in rat plasma using ultra performance liquid chromatography with tandem mass spectrometry. J Pharm Biomed Anal. 2016 Jul 15;126:98-102.|[2]Munshi N, et al. ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther. 2010 Jun;9 (6) :1544-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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