GR-73632
Product Specifications
UNSPSC Description
GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist[1]. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals[2].
Target Antigen
Neurokinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/gr-73632.html
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic)
Smiles
NCCCCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N([C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)C)=O)=O)=O)=O
Molecular Weight
766.00
References & Citations
[1]Sakurada C, et al. Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides. 1999;20(2):301-4.|[2]Costantini VJ, et al. The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration. Exp Dermatol. 2015 Apr;24(4):312-4.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1192/GR-73632-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1192/GR-73632-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
133156-06-6
Available Sizes
Curated Selection
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