Alborixin
Alborixin is an inhibitor of the PI3K-AKT pathway that induces autophagy. It promotes the clearance of intracellular and extracellular amyloid-β by upregulating autophagy-related proteins (such as BECN1, ATG5, ATG7) and enhancing lysosomal activity, thereby reducing amyloid-β-mediated neurotoxicity. Alborixin shows potential for research in Alzheimer's disease[1].
Product Specifications
CAS Number
57760-36-8
UNSPSC
12352005
Target
Akt; Autophagy; PI3K
Type
Natural Products
Related Pathways
Autophagy; PI3K/Akt/mTOR
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/alborixin.html
Smiles
O[C@@]1([C@]2(O[C@](CC2)([H])[C@H]([C@@]3(O[C@@H]([C@H](C[C@H]3C)C)C[C@]4(O[C@@](CC[C@@H]4C)([H])[C@@H](C)[C@H](O)C[C@@H]5O[C@]([C@H](C[C@H]5C)C)([H])[C@@H](C)C(O)=O)O)O)O)C)O[C@@](C[C@H]1C)([C@]6([H])O[C@H]([C@](O)(CC6)C)CC)C
Molecular Formula
C48H84O14
Molecular Weight
885.17
References & Citations
[1]Wani A, et al. Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Autophagy. 2019 Oct;15 (10) :1810-1828.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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