Alborixin
Product Specifications
UNSPSC Description
Alborixin is an inhibitor of the PI3K-AKT pathway that induces autophagy. It promotes the clearance of intracellular and extracellular amyloid-β by upregulating autophagy-related proteins (such as BECN1, ATG5, ATG7) and enhancing lysosomal activity, thereby reducing amyloid-β-mediated neurotoxicity. Alborixin shows potential for research in Alzheimer's disease[1].
Target Antigen
Akt; Autophagy; PI3K
Type
Natural Products
Related Pathways
Autophagy;PI3K/Akt/mTOR
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/alborixin.html
Smiles
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Molecular Weight
885.17
References & Citations
[1]Wani A, et al. Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Autophagy. 2019 Oct;15(10):1810-1828.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-167843/Alborixin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-167843/
Clinical Information
No Development Reported
CAS Number
57760-36-8
Curated Selection
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