Acifluorfen

Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen causes strong photooxidative destruction of pigments and lipids in sensitive plant species[1][2].

Product Specifications

CAS Number

[50594-66-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H410

Target

Herbicide

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/acifluorfen.html

Concentration

10mM

Purity

98.95

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC(OC2=CC=C(C(F)(F)F)C=C2Cl)=CC=C1[N+]([O-])=O

Molecular Formula

C14H7ClF3NO5

Molecular Weight

361.66

Precautions

H302, H315, H318, H410

References & Citations

[1]Kuwata K, et al. Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. Toxicol Sci. 2016;151 (2) :271-285.|[2]Kenyon WH, et al. Effects of Acifluorfen on Endogenous Antioxidants and Protective Enzymes in Cucumber (Cucumis sativus L.) Cotyledons. Plant Physiol. 1985;79 (3) :862-866.|[3]Hong T, et al. Exposure to acifluorfen induces developmental toxicity in the early life stage of zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2024 Jul;281:109909.