Acifluorfen
Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen causes strong photooxidative destruction of pigments and lipids in sensitive plant species[1][2].
Product Specifications
CAS Number
50594-66-6
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H410
Target
Herbicide
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/acifluorfen.html
Concentration
10mM
Purity
98.95
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC(OC2=CC=C(C(F)(F)F)C=C2Cl)=CC=C1[N+]([O-])=O
Molecular Formula
C14H7ClF3NO5
Molecular Weight
361.66
Precautions
H302, H315, H318, H410
References & Citations
[1]Kuwata K, et al. Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. Toxicol Sci. 2016;151 (2) :271-285.|[2]Kenyon WH, et al. Effects of Acifluorfen on Endogenous Antioxidants and Protective Enzymes in Cucumber (Cucumis sativus L.) Cotyledons. Plant Physiol. 1985;79 (3) :862-866.|[3]Hong T, et al. Exposure to acifluorfen induces developmental toxicity in the early life stage of zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2024 Jul;281:109909.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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