Fluralaner-d5

Fluralaner-d5 (A1443-d5) is deuterium labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels[1].

Product Specifications

Product Name Alternative

A1443-d5; AH252723-d5

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

O=C(NC([2H])([2H])C(NCC(F)(F)F)=O)C1=CC=C(C2=NOC(C(F)(F)F)(C3=C([2H])C(Cl)=C([2H])C(Cl)=C3[2H])C2)C=C1C

Molecular Formula

C22H12D5Cl2F6N3O3

Molecular Weight

561.32

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Williams H, et al. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in asimulated home environment. Parasit Vectors. 2014 Jun 19;7:275.|[3]Walther FM, et al. Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1 (-/-) Collies after oral administration. Parasit Vectors. 2014 Mar 6;7:86.