LZ-007
LZ-007 is an agonist for farnesoid X receptor (FXR) with an EC50 of 51 nM measuring by TR-FRET assay, or an EC50 of 76 nM in HepG2 cell. LZ-007 exhibits good pharmacokinetic characheristics in SD rats. LZ-007 ameliorates western diet and CCl4 -induced mice metabolic dysfunction-associated steatohepatitis[1]
Product Specifications
CAS Number
2920000-23-1
UNSPSC
12352005
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lz-007.html
Smiles
CC(C)C1=C(CN2CCC(COC3=CC=C(C(O)=O)C=C3)CC2)C(C4=CC=CC=C4OC(F)(F)F)=NO1
Molecular Formula
C27H29F3N2O5
Molecular Weight
518.52
References & Citations
[1]Wang W, et al., Design, synthesis, and biological evaluation of novel highly potent FXR agonists bearing piperidine scaffold. Eur J Med Chem. 2025 Jan 15;282:117082.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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