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LZ-007

LZ-007 is an agonist for farnesoid X receptor (FXR) with an EC50 of 51 nM measuring by TR-FRET assay, or an EC50 of 76 nM in HepG2 cell. LZ-007 exhibits good pharmacokinetic characheristics in SD rats. LZ-007 ameliorates western diet and CCl4 -induced mice metabolic dysfunction-associated steatohepatitis[1]

Product Specifications

CAS Number

2920000-23-1

UNSPSC

12352005

Target

FXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/lz-007.html

Smiles

CC(C)C1=C(CN2CCC(COC3=CC=C(C(O)=O)C=C3)CC2)C(C4=CC=CC=C4OC(F)(F)F)=NO1

Molecular Formula

C27H29F3N2O5

Molecular Weight

518.52

References & Citations

[1]Wang W, et al., Design, synthesis, and biological evaluation of novel highly potent FXR agonists bearing piperidine scaffold. Eur J Med Chem. 2025 Jan 15;282:117082.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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