What is the catalog number for Piclamilast?

The catalog number for Piclamilast is HY-12887.

What sizes are available for Piclamilast?

Piclamilast is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 50 mg.

How many pack sizes does Piclamilast come in?

Piclamilast is available in 5 different pack sizes.

Is Piclamilast in stock?

Piclamilast is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Piclamilast?

Piclamilast is manufactured by QuantiMol.

What is the estimated delivery time for Piclamilast?

Estimated delivery time for Piclamilast is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Piclamilast?

The safety data sheet for Piclamilast is available here: http://file.medchemexpress.com/batch_PDF/HY-12887/Piclamilast-SDS-MedChemExpress.pdf.

Piclamilast

Piclamilast (RP 73401) is a phosphodiesterase 4 (PDE4) inhibitor, with IC50 values of 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively[1][2][3][4].

Product Specifications

CAS Number

144035-83-6

Product Name Alternative

RP 73401; RPR 73401

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/piclamilast.html

Purity

99.74

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1=C(Cl)C=NC=C1Cl)C2=CC=C(OC)C(OC3CCCC3)=C2

Molecular Formula

C18H18Cl2N2O3

Molecular Weight

381.25

Precautions

H302, H315, H319, H335

References & Citations

[1]M J Ashton, et al. Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3- (cyclopentyloxy) -4-methoxybenzamides and analogues. J Med Chem. 1994 May 27;37 (11) :1696-703.|[2]Manuel Mata, et al. Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H (2) O (2) via mechanisms involving AP-1 activation. Free Radic Res. 2012 May;46 (5) :690-9.|[3]Edoardo Parrella, et al. Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways. J Biol Chem . 2004 Oct 1;279 (40) :42026-40.|[4]T Ukita, et al. Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives. J Med Chem. 1999 Mar 25;42 (6) :1088-99.