AM580 (GMP)
Product Specifications
UNSPSC Description
AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist[1][2][3][4].
Target Antigen
RAR/RXR
Type
GMP Small Molecules
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/am580-gmp.html
Purity
99.00
Solubility
10 mM in DMSO
Smiles
CC(CC1)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C1(C)C
Molecular Weight
351.44
References & Citations
[1]Zhao T, et al. Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming. Cell Stem Cell. 2018 Jul 5;23(1):31-45.e7. |[2]Cai A, et al. Neuroblastoma SH-SY5Y Cell Differentiation to Mature Neuron by AM580 Treatment. Neurochem Res. 2022 |[3]Gianní M, et al. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996 Feb 15;87(4):1520-31.|[4]Brok-Volchanskaya VS, et al. Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA. Stem Cell Reports. 2019 Dec 10;13(6):1099-1110.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10475G/AM580-GMP-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10475G/
Clinical Information
No Development Reported
CAS Number
102121-60-8
Available Sizes
Curated Selection
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