AM580 (GMP)

AM580 (CD336) (GMP) is AM580= (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist[1][2][3][4].

Product Specifications

CAS Number

[102121-60-8]

Product Name Alternative

CD336 (GMP) ; NSC608001 (GMP) ; Ro 40-6055 (GMP)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

RAR/RXR

Type

GMP Small Molecules

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/am580-gmp.html

Purity

99.4

Solubility

10 mM in DMSO

Smiles

CC(CC1)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C1(C)C

Molecular Formula

C22H25NO3

Molecular Weight

351.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhao T, et al. Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming. Cell Stem Cell. 2018 Jul 5;23 (1) :31-45.e7. |[2]Cai A, et al. Neuroblastoma SH-SY5Y Cell Differentiation to Mature Neuron by AM580 Treatment. Neurochem Res. 2022 |[3]Gianní M, et al. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996 Feb 15;87 (4) :1520-31.|[4]Brok-Volchanskaya VS, et al. Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA. Stem Cell Reports. 2019 Dec 10;13 (6) :1099-1110.