BMS-740808
BMS-740808 is a potent, selective and orally active factor Xa inhibitor with a Ki of 30 pM. BMS-740808 shows >1000-fold for factor Xa than other proteases[1].
Product Specifications
CAS Number
280118-23-2
UNSPSC
12352005
Target
Factor Xa
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bms-740808.html
Smiles
O=C1C2=C(CCN1C3=CC=C(C4=C(C=CC=C4)CN5CC[C@H](C5)O)C=C3)C(C(F)(F)F)=NN2C6=CC=C(ON=C7N)C7=C6
Molecular Formula
C31H27F3N6O3
Molecular Weight
588.58
References & Citations
[1]Donald J P Pinto, et al. 1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'- (3- (R) -hydroxy-N-pyrrolidinyl) methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. Bioorg Med Chem Lett. 2006 Aug 1;16 (15) :4141-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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