Captopril EP Impurity J

Captopril EP Impurity J is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) [1][2][3].

Product Specifications

CAS Number

[64838-55-7]

Product Name Alternative

S-Acetylcaptopril

UNSPSC

12352005

Hazard Statement

H317-H361-H372

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/captopril-ep-impurity-j.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(C([C@H](C)CSC(C)=O)=O)CCC1)O

Molecular Formula

C11H17NO4S

Molecular Weight

259.32

Precautions

P260-P261-P264-P270-P272-P280-P302+P352-P362+P364-P405-P501

References & Citations

[1]Li, Hp, et al. Synthesis and characterization of captopril derivatives. Res Chem Intermed 39, 621–629 (2013) .|[2]Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64 (11) :2263-2268.|[3]Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.