EGFR T790M/L858R-IN-6
Product Specifications
UNSPSC Description
EGFR T790M/L858R-IN-6 (compound 53), a pyrimidine compound, is a potent EGFR T790M/L858R inhibitor. EGFR T790M/L858R-IN-6 shows 90.88% enzyme activity inhibition with 0.05 μM[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-t790m-l858r-in-6.html
Solubility
10 mM in DMSO
Smiles
OCCNC1=CC(OC)=C(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)C=C1NC5=NC=CC=C5
Molecular Weight
481.55
References & Citations
[1]Guoqing Paul Chen, et al. Novel pyrimidine compound as kinase inhibitors with biological activities on egfr mutants. WO2024064091A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-158177/EGFR-T790M-L858R-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-158177/
Clinical Information
No Development Reported
CAS Number
3032760-71-4
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