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EGFR T790M/L858R-IN-6

Selected Variant

HY-158177

Size: 1 Each

EGFR T790M/L858R-IN-6 (compound 53), a pyrimidine compound, is a potent EGFR T790M/L858R inhibitor. EGFR T790M/L858R-IN-6 shows 90.88% enzyme activity inhibition with 0.05 μM[1].

Product Specifications

CAS Number

3032760-71-4

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-t790m-l858r-in-6.html

Solubility

10 mM in DMSO

Smiles

OCCNC1=CC(OC)=C(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)C=C1NC5=NC=CC=C5

Molecular Formula

C27H27N7O2

Molecular Weight

481.55

References & Citations

[1]Guoqing Paul Chen, et al. Novel pyrimidine compound as kinase inhibitors with biological activities on egfr mutants. WO2024064091A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1

Price

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