Saccharopine

Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3].

Product Specifications

CAS Number

[997-68-2]

Product Name Alternative

L-Saccharopine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/saccharopine.html

Purity

97.51

Solubility

DMSO : 8.3 mg/mL (ultrasonic; warming)

Smiles

OC([C@@H](NCCCC[C@H](N)C(O)=O)CCC(O)=O)=O

Molecular Formula

C11H20N2O6

Molecular Weight

276.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhou J, et, al. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. J Cell Biol. 2019 Feb 4;218 (2) :580-597.|[2]Leandro J, et, al. Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. J Cell Biol. 2019 Feb 4;218 (2) :391-392.|[3]Papes F, et, al. Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem J. 1999 Dec 1;344 Pt 2 (Pt 2) :555-63.