SelB-1
SelB-1 serves as a dual inhibitor for Topoisomerase I/II. SelB-1 possesses anticancer activity and can be utilized in the research of prostate cancer and colon cancer. Furthermore, SelB-1 is also capable of inducing autophagy gene expression and lipid peroxidation, while simultaneously reducing the level of GSH[1].
Product Specifications
CAS Number
2674058-66-1
UNSPSC
12352005
Target
Autophagy; Glutathione Peroxidase; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/selb-1.html
Smiles
O=C(C1=CC(C2=CC=C(O)C=C2)=C(C3=CC=C(O)C=C3)C(C4=CC=C(O)C=C4)=C1)C5=CC=C(OC)C=C5
Molecular Formula
C32H24O5
Molecular Weight
488.53
References & Citations
[1]Dönmez S, et al. Selagibenzophenone B and Its Derivatives: SelB-1, a Dual Topoisomerase I/II Inhibitor Identified through In Vitro and In Silico Analyses. ACS Bio Med Chem Au. 2024 Jul 26;4 (4) :178-189.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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