SelB-1

SelB-1 serves as a dual inhibitor for Topoisomerase I/II. SelB-1 possesses anticancer activity and can be utilized in the research of prostate cancer and colon cancer. Furthermore, SelB-1 is also capable of inducing autophagy gene expression and lipid peroxidation, while simultaneously reducing the level of GSH[1].

Product Specifications

CAS Number

[2674058-66-1]

UNSPSC

12352005

Target

Autophagy; Glutathione Peroxidase; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/selb-1.html

Smiles

O=C(C1=CC(C2=CC=C(O)C=C2)=C(C3=CC=C(O)C=C3)C(C4=CC=C(O)C=C4)=C1)C5=CC=C(OC)C=C5

Molecular Formula

C32H24O5

Molecular Weight

488.53

References & Citations

[1]Dönmez S, et al. Selagibenzophenone B and Its Derivatives: SelB-1, a Dual Topoisomerase I/II Inhibitor Identified through In Vitro and In Silico Analyses. ACS Bio Med Chem Au. 2024 Jul 26;4 (4) :178-189.