Anti-DC-UbP Antibody

Rabbit Polyclonal Antibody specific to DC-UbP

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Dendritic cell-derived ubiquitin-like protein, DC-UbP, Ubiquitin-like protein SB72

Gene Name

UBTD2

Gene ID

92181

NCBI Gene ID

UniProt

Q8WUN7

Accession Number

NP_689490.2

Cellular Locus

Cytoplasm

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids 197-212 (SGRPLTDKMKFEELKI) of human DC-UbP precursor conjugated to KLH at the N-terminus. This sequence is 93

Target Antigen

Ubiquitin domain-containing protein 2

Target

DC-UbP

Clonality

Polyclonal

Type

Antibody

Applications

WB, ELISA

Field of Research

Apoptosis

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Additionnal Information

ELISA: 1:1,000-1:10,000 with Dc-UbP on the solid phase. <br><br>The investigator should determine the optimal dilution for their application.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Specificity

This antibody recognizes human, mouse, and rat DC-UbP.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

DC-UbP is a 26 kDa ubiquitin-like protein from dendritic cells comprised of 106 amino acids. The ubiquitin domain in DC-UbP shares 28.6% identity with ubiquitin, but it does not have the conserved C-terminus Gly-Gly of ubiquitin required for ubiquitinization. DC-UbP is found in cytoplasm (particularly in mitochondria), and DC- UbP mRNA is expressed in various tumor cell types, but not in normal adult human tissues, which suggests a role for DC-UbP in tumorigenesis. In addition, DC-UbP appears to be downregulated during cellular differentiation and apoptosis.