JTK-101
JTK-101 is a selective HIV inhibitor. JTK-101 selectively reduces HIV-1 mRNA synthesis by inhibiting Tat cofactors, including CDK9 and cyclin T1, thereby suppressing the transcriptional activity of HIV-1. JTK-101 may be used in the field of anti-HIV virus research[1].
Product Specifications
CAS Number
503048-34-8
UNSPSC
12352005
Target
CDK; HIV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jtk-101.html
Smiles
N#CC1=CC=C(C=C1)CN2CCC(CC2)(OC3=C4C=C(C=CC4=CC=C35)OC)NC5=O
Molecular Formula
C25H23N3O3
Molecular Weight
413.47
References & Citations
[1]Wang X, et al. Potent and selective inhibition of Tat-dependent HIV-1 replication in chronically infected cells by a novel naphthalene derivative JTK-101. Antivir Chem Chemother. 2007;18 (4) :201-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9; HIV-1
Frequently Asked Questions
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