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Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32)

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived anti-LPAM-1/Integrin α4β7 IgG2a, κ type antibody inhibitor. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) specifically reacts with both chains of the α4β7 heterodimer and blocks the adhesion to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1) . Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) suppresses the proliferation and cytokine secretion of CD8+ T cells. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) decreases Peyer’s patches and follicular B cells in mice. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) can be used for the researches of inflammation, such as ulcerative colitis[1][2][3][4].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

Integrin

Type

Inhibitory Antibodies

Related Pathways

Cytoskeleton

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-lpam-1-integrin-α4β7-antibody-datk32.html

Purity

97

Solubility

10 mM in DMSO

Smiles

[Anti-MouseLPAM-1/Integrina4b7Antibody(DATK32)]

Molecular Weight

(150 kDa)

References & Citations

[1]Katayama Y, et al. Integrin alpha4beta7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation. Blood. 2004 Oct 1;104 (7) :2020-6. |[2]Fernekorn U, et al. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Eur J Immunol. 2004 Dec;34 (12) :3423-33.|[3]Su Z, Bian L, et al. Gut-tropic α4β7+CD8+ T cells contribute to pancreatic β cell destruction in type 1 diabetes. Front Immunol. 2025 Jul 10;16:1623428.|[4]P Canales-Herrerias, et al. P061 Response to anti-α4β7 therapy in Ulcerative colitis is associated with lymphoid aggregate attrition through impaired recruitment of naïve lymphocytes, Journal of Crohn's and Colitis, Volume 17, Issue Supplement_1, February 2023, Pages i227–i228.

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4°C for 2 years, do not freeze

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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