8RK59
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 using copper (I) -mediated click chemistry, resulting in compound 8RK59[1].
Product Specifications
CAS Number
2705841-53-6
UNSPSC
12171500
Target
Deubiquitinase
Type
Dye Reagents
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8rk59.html
Purity
99.2
Solubility
10 mM in DMSO
Smiles
O=C(N1CC2=C(N=C(S2)NC([C@@H]3CN(CC3)C#N)=O)CC1)CN(N=N4)C=C4CCCCC(C5=C(C)C=C(C)[N-]5[B+3]([F-])6[F-])=C7[N]6=C(C)C=C7C
Molecular Formula
C33H39BF2N10O2S
Molecular Weight
688.60
References & Citations
[1]Kooij R, et al. Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142 (39) :16825-16841.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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