3-Aminobenzamide

3-Aminobenzamide (PARP-IN-1) is a potent inhibitor of PARP with IC50 of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.

Product Specifications

CAS Number

[3544-24-9]

Product Name Alternative

PARP-IN-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/INO-1001.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 11.11 mg/mL

Smiles

O=C(C1=CC=CC(N)=C1)N

Molecular Formula

C7H8N2O

Molecular Weight

136.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Brock WA, et al. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly (ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18;205 (2) :155-60.|[2]Radovits T, et al. Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. Eur J Pharmacol. 2007 Jun 14;564 (1-3) :158-66.|[3]Szabo C, et al. Poly (ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes. 2006 Nov;55 (11) :3004-12.|[4]Clark RS, et al. Local administration of the poly (ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice. J Neurotrauma. 2007 Aug;24 (8) :1399-405.