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PI3K-IN-54

PI3K-IN-54 (compound 10w) is a pan-PI3K inhibitor. The IC50 values of PI3K-IN-54 for p110α, p110β, and p110δ are 0.22 nM, 1.4 nM, and 0.38 nM, respectively. PI3K-IN-54 can be used in cancer research[1].

Product Specifications

CAS Number

1336890-05-1

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3k-in-54.html

Smiles

FC(C1=NC2=C(N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)C=C(N)C=C2OC)F

Molecular Formula

C20H24F2N8O3

Molecular Weight

462.45

References & Citations

[1]Rewcastle GW, et al. Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2- (difluoromethyl) -1-[4,6-di (4-morpholinyl) -1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474) . J Med Chem. 2011 Oct 27;54 (20) :7105-26.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PI3Kα; PI3Kβ; PI3Kδ

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