PI3K-IN-54
PI3K-IN-54 (compound 10w) is a pan-PI3K inhibitor. The IC50 values of PI3K-IN-54 for p110α, p110β, and p110δ are 0.22 nM, 1.4 nM, and 0.38 nM, respectively. PI3K-IN-54 can be used in cancer research[1].
Product Specifications
CAS Number
1336890-05-1
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3k-in-54.html
Smiles
FC(C1=NC2=C(N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)C=C(N)C=C2OC)F
Molecular Formula
C20H24F2N8O3
Molecular Weight
462.45
References & Citations
[1]Rewcastle GW, et al. Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2- (difluoromethyl) -1-[4,6-di (4-morpholinyl) -1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474) . J Med Chem. 2011 Oct 27;54 (20) :7105-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kδ
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