What is the catalog number for Anti-EGFR PE-Cy™7?

The catalog number for Anti-EGFR PE-Cy™7 is T7-680-T100.

What sizes are available for Anti-EGFR PE-Cy™7?

Anti-EGFR PE-Cy™7 is available in the following size(s): 100 Tests.

Is Anti-EGFR PE-Cy™7 in stock?

Anti-EGFR PE-Cy™7 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-EGFR PE-Cy™7?

Anti-EGFR PE-Cy™7 is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-EGFR PE-Cy™7?

Estimated delivery time for Anti-EGFR PE-Cy™7 is approximately 10 business day(s), depending on your location.

Anti-EGFR PE-Cy™7

The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.

Product Specifications

Certification

RUO

Negative Species

Mouse,Rat

Reactivity

Horse, Human

Immunogen

Human epidermoid carcinoma line A431

Target Antigen

EGFR

Clone

EGFR1

Applications

FC (QC tested)

Format

PE-Cy

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Fortunel NO, Hatzfeld JA, Rosemary PA, Ferraris C, Monier MN, Haydont V, Longuet J, Brethon B, Lim B, Castiel I, Schmidt R, Hatzfeld A: Long-term expansion of human functional epidermal precursor cells: promotion of extensive amplification by low TGF-beta1 concentrations. J Cell Sci. 2003 Oct 1;116 (Pt 19) :4043-52., URL: http://www.ncbi.nlm.nih.gov/pubmed/12953061 , *Aigner A, Juhl H, Malerczyk C, Tkybusch A, Benz CC, Czubayko F: Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation. Oncogene. 2001 Apr 19;20 (17) :2101-11. (FC), URL: https://www.ncbi.nlm.nih.gov/pubmed/11360194, *Akiyama M, Smith LT, Shimizu H: Changing patterns of localization of putative stem cells in developing human hair follicles. J Invest Dermatol. 2000 Feb;114 (2) :321-7. (IHC-F), URL: https://www.ncbi.nlm.nih.gov/pubmed/10651993, *Rebetz J, Tian D, Persson A, Widegren B, Salford LG, Englund E, Gisselsson D, Fan X: Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma. PLoS One. 2008 Apr 9;3 (4) :e1936. (FC), URL: http://www.ncbi.nlm.nih.gov/pubmed/18398462