Anti-EGFR PE-Cy™7
The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
Product Specifications
Certification
RUO
Negative Species
Mouse,Rat
Immunogen
Human epidermoid carcinoma line A431
Target Antigen
EGFR
Clone
EGFR1
Applications
FC (QC tested)
Format
PE-Cy™7
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1) ; epitope within amino acids 6-273.
Applications Notes
6
Species
Horse, Human
CAS Number
9007-83-4
Isotype
Mouse IgG2b kappa
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items