Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Hu CD184 PE-Cy™7

CD184, also known as CXCR4 or fusin, is a receptor for the C-X-C chemokine SDF-1. It is expressed mainly in hematopoietic cells, vascular endothelium, and neural tissue. CD184 is a G-protein coupled receptor containing extracellular N-terminal, seven transmembrane domains and intracellular C-terminal domain. It transduces signal by increasing the intracellular calcium level. CD184 plays an essential role in vascularization of the gastrointestinal tract, and is involved in cerebellar development and in hematopoiesis. It is also a coreceptor (with CD4) for HIV-1 X4 virus and a primary receptor for some HIV-2 isolates.

Product Specifications

Certification

RUO

Immunogen

CP-MAC-infected Sup-T1 cells

Target Antigen

CD184

Clone

12G5

Applications

FC (QC tested)

Format

PE-Cy™7

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Koopman G, Mortier D, Hofman S, Koutsoukos M, Bogers WM, Wahren B, Voss G, Heeney JL: Acute-phase CD4+ T-cell proliferation and CD152 upregulation predict set-point virus replication in vaccinated simian-human immunodeficiency virus strain 89.6p-infected macaques. J Gen Virol. 2009 Apr;90 (Pt 4) :915-26., URL: http://www.ncbi.nlm.nih.gov/pubmed/19223489 , *Campioni D, Zauli G, Gambetti S, Campo G, Cuneo A, Ferrari R, Secchiero P: In vitro characterization of circulating endothelial progenitor cells isolated from patients with acute coronary syndrome. PLoS One. 2013;8 (2) :e56377., URL: http://www.ncbi.nlm.nih.gov/pubmed/23409178 , *Uy GL, Rettig MP, Motabi IH, McFarland K, Trinkaus KM, Hladnik LM, Kulkarni S, Abboud CN, Cashen AF, Stockerl-Goldstein KE, Vij R, Westervelt P, DiPersio JF: A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia. Blood. 2012 Apr 26;119 (17) :3917-24., URL: https://pubmed.ncbi.nlm.nih.gov/22308295/, *Grundler R, Brault L, Gasser C, Bullock AN, Dechow T, Woetzel S, Pogacic V, Villa A, Ehret S, Berridge G, Spoo A, Dierks C, Biondi A, Knapp S, Duyster J, Schwaller J: Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. J Exp Med. 2009 Aug 31;206 (9) :1957-70., URL: https://pubmed.ncbi.nlm.nih.gov/19687226/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 12G5 recognizes an extracellular epitope of CD184, a 45 kDa G-protein-linked CXC chemokine receptor widely expressed on blood and tissue cells.

Applications Notes

6

Species

Human, Non-human primates

CAS Number

9007-83-4

Isotype

Mouse IgG2a kappa

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MUC13 Rabbit Polyclonal Antibody
TA356351 100 µL

MUC13 Rabbit Polyclonal Antibody

Ask
View Details
LTA4H (Leukotriene A4 Hydrolase) Chicken ELISA Kit
E7516 96 Tests

LTA4H (Leukotriene A4 Hydrolase) Chicken ELISA Kit

Ask
View Details
SQLE AAV Vector (Human) (CMV)
45432101 1 μg

SQLE AAV Vector (Human) (CMV)

Ask
View Details
SPATA18 shRNA (h) Lentiviral Particles
sc-89204-V 200 µL

SPATA18 shRNA (h) Lentiviral Particles

Ask
View Details
NDUF3 (NDUFAF3) Human qPCR Template Standard (NM_199074)
HK212519 1 Kit

NDUF3 (NDUFAF3) Human qPCR Template Standard (NM_199074)

Ask
View Details
Tmprss4 AAV siRNA Pooled Vector
47150164 1.0 μg

Tmprss4 AAV siRNA Pooled Vector

Ask
View Details