Anti-Hu CD300e Pacific Blue™
CD300e / IREM-2 (immune receptor expressed by myeloid cells 2), also known as CLM2 or LMIR6, is a monomeric transmembrane glycoprotein with a single extracellular immunoglobulin-like domain. Intracellularly it associates with DAP-12, an ITAM-containing adaptor molecule. CD300e is expressed on mature monocytes and peripheral blood myeloid dendritic cells. Its crosslinking leads to release of pro-inflammatory cytokines, and increased expression of activation markers.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
CD300e-HA-transfected cells
Target Antigen
CD300e
Clone
UP-H2
Applications
FC (QC tested)
Format
Pacific Blue
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Aguilar H, Alvarez-Errico D, García-Montero AC, Orfao A, Sayós J, López-Botet M: Molecular characterization of a novel immune receptor restricted to the monocytic lineage. J Immunol. 2004 Dec 1;173 (11) :6703-11., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=aguilar+h+orfao+a, *Brckalo T, Calzetti F, Pérez-Cabezas B, Borrà s FE, Cassatella MA, López-Botet M: Functional analysis of the CD300e receptor in human monocytes and myeloid dendritic cells. Eur J Immunol. 2010 Mar;40 (3) :722-32., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=brckalo+t+calzetti
Other References
*Clark GJ, Ju X, Tate C, Hart DN: The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions. Trends Immunol. 2009 May;30 (5) :209-17., URL: http://www.ncbi.nlm.nih.gov/pubmed/19359216
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody UP-H2 recognizes an extracellular epitope on CD300e / IREM-2, a 32 kDa glycoprotein expressed by mature monocytes and peripheral blood myeloid dendritic cells.
Applications Notes
6
Isotype
Mouse IgG1 kappa
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