Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Ms CD8a Pacific Blue™

The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.

Product Specifications

Certification

RUO

Reactivity

Mouse

Immunogen

Murine spleen cells

Target Antigen

CD8a

Clone

53-6.7

Applications

FC (QC tested)

Concentration

0.5 mg/mL

Format

Pacific Blue

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Mochimaru H, Usui T, Yaguchi T, Nagahama Y, Hasegawa G, Usui Y, Shimmura S, Tsubota K, Amano S, Kawakami Y, Ishida S: Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2. Invest Ophthalmol Vis Sci. 2008 May;49 (5) :2172-7., URL: https://www.ncbi.nlm.nih.gov/pubmed/18263815?ordin, *Bouwer HG, Alberti-Segui C, Montfort MJ, Berkowitz ND, Higgins DE: Directed antigen delivery as a vaccine strategy for an intracellular bacterial pathogen. Proc Natl Acad Sci U S A. 2006 Mar 28;103 (13) :5102-7., URL: https://www.ncbi.nlm.nih.gov/pubmed/16549792?ordin, *Kamimura D, Sawa Y, Sato M, Agung E, Hirano T, Murakami M: IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb. J Immunol. 2006 Jul 1;177 (1) :306-14., URL: https://www.ncbi.nlm.nih.gov/pubmed/16785526?ordin, *Kosy, Ko HJ, Chang WS, Park SH, Kweon MN, Kang CY: alpha-Galactosylceramide can act as a nasal vaccine adjuvant inducing protective immune responses against viral infection and tumor. J Immunol. 2005 Sep 1;175 (5) :3309-17., URL: https://www.ncbi.nlm.nih.gov/pubmed/16116223?ordin, *Grabbe S, Varga G, Beissert S, Steinert M, Pendl G, Seeliger S, Bloch W, Peters T, Schwarz T, Sunderkötter C, Scharffetter-Kochanek K: Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells. J Clin Invest. 2002 Jan;109 (2) :183-92., URL: https://www.ncbi.nlm.nih.gov/pubmed/11805130?ordin, *Hata H, Sakaguchi N, Yoshitomi H, Iwakura Y, Sekikawa K, Azuma Y, Kanai C, Moriizumi E, Nomura T, Nakamura T, Sakaguchi S. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest. 2004 Aug;114 (4) :582-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/15314695?ordin, *Takahashi K, Nakata M, Tanaka T, Adachi H, Nakauchi H, Yagita H, Okumura K: CD4 and CD8 regulate interleukin 2 responses of T cells. Proc Natl Acad Sci U S A. 1992 Jun 15;89 (12) :5557-61., URL: https://www.ncbi.nlm.nih.gov/pubmed/1608966?ordina, *Ledbetter JA, Rouse RV, Micklem HS, Herzenberg LA: T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J Exp Med. 1980 Aug 1;152 (2) :280-95., URL: https://www.ncbi.nlm.nih.gov/pubmed/6156984?ordina, *Ledbetter JA, Herzenberg LA: Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol Rev. 1979;47:63-90., URL: https://www.ncbi.nlm.nih.gov/pubmed/398327?ordinal

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The rat monoclonal antibody 53-6.7 recognizes an extracellular epitope of murine CD8a (32-34 kDa; alpha chain of the CD8 antigen) .

Applications Notes

Flow cytometry: Recommended dilution: 2-3 μg/ml.

Isotype

Rat IgG2a kappa

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Human FASTK activation kit by CRISPRa
GA107490 1 Kit

Human FASTK activation kit by CRISPRa

Sign In for Pricing
View Details
TAG-72 / CA72.4 (B72.3 + CA72/733), CF405S conjugate, 0.1mg/mL
BNC040734-500 1x 500 µL

TAG-72 / CA72.4 (B72.3 + CA72/733), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
IL28 Receptor alpha (IFNLR1) Rabbit Polyclonal Antibody
TA368540 100 µL

IL28 Receptor alpha (IFNLR1) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
Tpo Mouse Gene Knockout Kit (CRISPR)
KN518096 1 Kit

Tpo Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
LY6E (NM_001127213) Human Over-expression Lysate
LC426714 20 µg

LY6E (NM_001127213) Human Over-expression Lysate

Sign In for Pricing
View Details
Cumylamine
TRC-C834700-5G 5 g

Cumylamine

Sign In for Pricing
View Details