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Anti-Hu Ig Kappa Light Chain Pacific Blue™

Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five heavy chains types) and two light chains (kappa, lambda; both having a molecular weight of 22.5kDa) . Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of kappa to lambda is 70:30.

Product Specifications

Certification

RUO

Negative Species

Rabbit,Hamster,Sheep,Guinea pig,Goat

Reactivity

Human

Target Antigen

Ig Kappa Light Chain

Clone

A8B5

Applications

FC (QC tested)

Format

Pacific Blue

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Diaz de Domingo NB, Lardo MM, Romero Artaza J, Merelli A, Carbia CD, Sánchez Avalos JC: Aplicacion de tecnicas inmunocitoquimicas para el diagnostico de neoplasias hematologicas. Medicina (B Aires) . 1999;59 (1) :11-6., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=lardo+mm+artaza+jr+merelli+a , *Scheeren FA, Diehl SA, Smit LA, Beaumont T, Naspetti M, Bende RJ, Blom B, Karube K, Ohshima K, van Noesel CJ, Spits H: IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis. Blood. 2008 May 1;111 (9) :4706-15. doi: 10.1182/blood-2007-08-105643, URL: http://www.ncbi.nlm.nih.gov/pubmed/18296629 , *Di Bartolo DL, Hyjek E, Keller S, Guasparri I, Deng H, Sun R, Chadburn A, Knowles DM, Cesarman E: Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma. J Virol. 2009 May;83 (9) :4308-15. doi: 10.1128/JVI.02196-08., URL: http://www.ncbi.nlm.nih.gov/pubmed/19224997 , *Konig A, Wennemuth G, Soyer HP, Hoffmann R, Happle R, Krause W: Vulvar amyloidosis mimicking giant condylomata acuminata in a patient with multiple myeloma. Eur J Dermatol. 1999 Jan-Feb;9 (1) :29-31., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=konig+a+wennemuth+g+soyer+hp, *Avilés-Salas A, Chanona-Vilchis JG, Candelaria-Hernández MG, Peñ a-Torres Mde L, Cuéllar-Mendoza ME: Presentación inicial de un linfoma plasmablástico como tumor ovárico. Ginecol Obstet Mex. 2012 Jun;80 (6) :430-4., URL: http://www.ncbi.nlm.nih.gov/pubmed/22826973

Other References

*Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh) . 1975;194:77-95., URL: https://www.ncbi.nlm.nih.gov/pubmed/47690?ordinalp

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody A8B5 reacts with kappa light chains (22.5 kDa) of immunoglobulins.

Applications Notes

6

Isotype

Mouse IgG1

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