Anti-Hu CD41a Pacific Blue™

*Wu XW., Chen Z., Bao CX., et al., 1989: Production and application of anti-human platelet GPIIb/IIIa monoclonal antibodies. National Medical J. of China. 69 (8) :427, URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=2620270&query_hl=7&itool=pubmed_docsum

*Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W: Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development. 2002 Apr;129 (8) :2003-13., URL: https://www.ncbi.nlm.nih.gov/pubmed/11934866?ordin, *Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC: CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development. 2003 Sep;130 (18) :4393-403., URL: https://www.ncbi.nlm.nih.gov/pubmed/12900455?ordin, *Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T: CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. Exp Hematol. 2007 Mar;35 (3) :490-499., URL: https://www.ncbi.nlm.nih.gov/pubmed/17309829?ordin, *Debili N, Robin C, Schiavon V, Letestu R, Pflumio F, Mitjavila-Garcia MT, Coulombel L, Vainchenker W: Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. Blood. 2001 Apr 1;97 (7) :2023-30., URL: https://www.ncbi.nlm.nih.gov/pubmed/11264167?ordin

The antibody HIP8 reacts with an extracellular epitope on alpha (a) subunit of CD41 (heavy chain; 120 kDa) . CD41 is mainly expressed on platelets and megakaryocytes. The antibody HIP8 blocks platelet aggregation and completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. HIP8 is useful in the morphological and physiological studies o platelets and megakaryocytes.