What is the catalog number for Anti-Hu CD27 Pacific Blue™?

The catalog number for Anti-Hu CD27 Pacific Blue™ is PB-308-T100.

What sizes are available for Anti-Hu CD27 Pacific Blue™?

Anti-Hu CD27 Pacific Blue™ is available in the following size(s): 100 Tests.

Is Anti-Hu CD27 Pacific Blue™ in stock?

Anti-Hu CD27 Pacific Blue™ is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD27 Pacific Blue™?

Anti-Hu CD27 Pacific Blue™ is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD27 Pacific Blue™?

Estimated delivery time for Anti-Hu CD27 Pacific Blue™ is approximately 10 business day(s), depending on your location.

Anti-Hu CD27 Pacific Blue™

CD27 is a transmembrane 55 kDa protein of the nerve growth factor-receptor family, expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. This sCD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Human peripheral blood lymphocytes

Target Antigen

CD27

Clone

LT27

Applications

FC (QC tested)

Format

Pacific Blue

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Kanderova V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, Hrusak O, Lund-Johansen F, Kalina T: High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016 Apr;15 (4) :1246-61., URL: http://www.ncbi.nlm.nih.gov/pubmed/26785729

Other References

*Yun LW, Decarlo AA, Hunter N: Blockade of protease-activated receptors on T cells correlates with altered proteolysis of CD27 by gingipains of Porphyromonas gingivalis. Clin Exp Immunol. 2007 Nov;150 (2) :217-29., URL: https://www.ncbi.nlm.nih.gov/pubmed/17937677?ordin, *Kara IO, Sahin B, Gunesacar R: Expression of soluble CD27 and interleukins-8 and -10 in B-cell chronic lymphocytic leukemia: correlation with disease stage and prognosis. Adv Ther. 2007 Jan-Feb;24 (1) :29-40., URL: https://www.ncbi.nlm.nih.gov/pubmed/17526459?ordin, *Molica S, Vitelli G, Levato D, Crispino G, Dell'Olio M, Dattilo A, Matera R, Gandolfo GM, Musto P. CD27 in B-cell chronic lymphocytic leukemia. Cellular expression, serum release and correlation with other soluble molecules belonging to nerve growth factor receptors (NGFr) superfamily. Haematologica. 1998 May;83 (5) :398-402., URL: https://www.ncbi.nlm.nih.gov/pubmed/9658722?ordina, *van Oers MH, Pals ST, Evers LM, van der Schoot CE, Koopman G, Bonfrer JM, Hintzen RQ, von dem Borne AE, van Lier RA: Expression and release of CD27 in human B-cell malignancies. Blood. 1993 Dec 1;82 (11) :3430-6., URL: https://www.ncbi.nlm.nih.gov/pubmed/8241510?ordina

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The antibody LT27 reacts with an extracellular epitope of CD27 (T14), a 50-55 kDa type I transmembrane glycoprotein (member of the TNF-receptor superfamily) expressed on medullary thymocytes, peripheral T lymphocytes, some B lymphocytes and NK cells.