Anti-Hu CD44 Pacific Blue™
CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Leukocytes of a patient suffering from LGL Type Leukaemia.
Target Antigen
CD44
Clone
MEM-85
Applications
FC (QC tested)
Format
Pacific Blue
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
Other References
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
Applications Notes
6
Isotype
Mouse IgG2b
Frequently Asked Questions
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