What is the catalog number for Anti-Hu CD129 PE?

The catalog number for Anti-Hu CD129 PE is 1P-788-T100.

What sizes are available for Anti-Hu CD129 PE?

Anti-Hu CD129 PE is available in the following size(s): 100 Tests.

Is Anti-Hu CD129 PE in stock?

Anti-Hu CD129 PE is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD129 PE?

Anti-Hu CD129 PE is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD129 PE?

Estimated delivery time for Anti-Hu CD129 PE is approximately 10 business day(s), depending on your location.

Anti-Hu CD129 PE

CD129 serves as the high affinity alpha subunit of IL-9 receptor. It associates with CD132, the common gamma chain shared by receptors of many different cytokines. CD129 is expressed at low levels by T and B cells, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons. Its signaling (through JAK/STAT pathways) results in proliferative and anti-apoptotic response, which is critical e.g. for intrathymic T cell development and survival of various cell types. The gene for CD129 is located at the pseudoautosomal regions of X and Y chromosomes and it may be related with the development of asthma.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Human CD129-transfected cell line

Target Antigen

CD129

Clone

AH9R7

Applications

FC (QC tested)

Format

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*De Smedt M, Verhasselt B, Kerre T, Vanhecke D, Naessens E, Leclercq G, Renauld JC, Van Snick J, Plum J: Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development. J Immunol. 2000 Feb 15;164 (4) :1761-7., URL: https://www.ncbi.nlm.nih.gov/pubmed/10657622, *Grasso L, Huang M, Sullivan CD, Messler CJ, Kiser MB, Dragwa CR, Holroyd KJ, Renauld JC, Levitt RC, Nicolaides NC: Molecular analysis of human interleukin-9 receptor transcripts in peripheral blood mononuclear cells. Identification of a splice variant encoding for a nonfunctional cell surface receptor. J Biol Chem. 1998 Sep 11;273 (37) :24016-24., URL: https://www.ncbi.nlm.nih.gov/pubmed/9727018, *Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y: IL-9 inhibits oxidative burst and TNF-alpha release in lipopolysaccharide-stimulated human monocytes through TGF-beta. J Immunol. 2002 Apr 15;168 (8) :4103-11. , URL: http://www.ncbi.nlm.nih.gov/pubmed/11937570 De Sme, *Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y: Oxidative burst in lipopolysaccharide-activated human alveolar macrophages is inhibited by interleukin-9. Eur Respir J. 2002 Nov;20 (5) :1198-205., URL: http://www.ncbi.nlm.nih.gov/pubmed/12449174 Grasso

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody AH9R7 recognizes an extracellular epitope of CD129 / IL-9R alpha, a 57 kDa type I transmembrane glycoprotein expressed at low levels by lymphocytes, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons.