Anti-Hu CD101 PE
CD101 is a type I transmembrane glycoprotein, which forms disulfide-linked homodimers. It is expressed on activated T cells, as well as on granulocytes, monocytes, dendritic cells or mucosal T cells. It plays a major role in the activation of T cells by skin dendritic cells. Function of CD101 has not been fully elucidated, but in mice its knock-out results in liver autoimmune disease induced by Novosphingobium aromaticivorans.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Human thymic clone B12
Target Antigen
CD101
Clone
BB27
Applications
FC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Bagot M, Martinel I, Charue D, Boulland ML, Wechsler J, Bensussan A, Boumsell L: Functional role of CD101 on skin dendritic cells. Adv Exp Med Biol. 1997;417:227-32., URL: http://www.ncbi.nlm.nih.gov/pubmed/9286366 Bagot M, *Grassi F, Dezutter-Dambuyant C, McIlroy D, Jacquet C, Yoneda K, Imamura S, Boumsell L, Schmitt D, Autran B, Debré P, Hosmalin A: Monocyte-derived dendritic cells have a phenotype comparable to that of dermal dendritic cells and display ultrastructural granules distinct from Birbeck granules. J Leukoc Biol. 1998 Oct;64 (4) :484-93., URL: https://pubmed.ncbi.nlm.nih.gov/9766629/
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody BB27 recognizes an extracellular epitope of CD101, a 140 kDa disulfide-bonded homodimeric protein expressed on activated T cells, and some other cell types, such as granulocytes and cells of the monocyte/macropgage lineage.
Applications Notes
6
Isotype
Mouse IgG1
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