Anti-Ms CD26 PE

CD26, also known as dipeptidyl peptidase IV (DPP-IV), is a homodimeric cell surface serine peptidase that degradates IFN-gamma-induced cytokines, acts as a T cell costimulatory molecule, and participates in multiple immunopathological roles in leukocyte homing and inflammation. Alterations in its peptidase activity are characteristic of malignant transformation. The enzymatic activity increases dramatically with tumour grade and severity. CD26 is expressed in various blood cell types, but also e.g. in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.

Product Specifications

Certification

RUO

Reactivity

Mouse

Immunogen

BALB/c thymocytes

Target Antigen

CD26

Clone

H194-112

Applications

FC (QC tested)

Concentration

0.5 mg/mL

Format

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Niedermeyer J, Kriz M, Hilberg F, Garin-Chesa P, Bamberger U, Lenter MC, Park J, Viertel B, Püschner H, Mauz M, Rettig WJ, Schnapp A: Targeted disruption of mouse fibroblast activation protein. Mol Cell Biol. 2000 Feb;20 (3) :1089-94., URL: http://www.ncbi.nlm.nih.gov/pubmed/10629066 , *James MJ, Belaramani L, Prodromidou K, Datta A, Nourshargh S, Lombardi G, Dyson J, Scott D, Simpson E, Cardozo L, Warrens A, Szydlo RM, Lechler RI, Marelli-Berg FM: Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism. Blood. 2003 Sep 15;102 (6) :2173-9., URL: https://pubmed.ncbi.nlm.nih.gov/12775572/, *Dorrell C, Erker L, Lanxon-Cookson KM, Abraham SL, Victoroff T, Ro S, Canaday PS, Streeter PR, Grompe M: Surface markers for the murine oval cell response. Hepatology. 2008 Oct;48 (4) :1282-91., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=abraham+sl+victoroff+t , *Marguet D, Baggio L, Kobayashi T, Bernard AM, Pierres M, Nielsen PF, Ribel U, Watanabe T, Drucker DJ, Wagtmann N: Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc Natl Acad Sci U S A. 2000 Jun 6;97 (12) :6874-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=marguet+d+baggio+l, *Adams S, Miller GT, Jesson MI, Watanabe T, Jones B, Wallner BP: PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Cancer Res. 2004 Aug 1;64 (15) :5471-80., URL: http://www.ncbi.nlm.nih.gov/pubmed/15289357

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The rat monoclonal antibody H194-112 recognizes an extracellular epitope of CD26, a 110 kDa type II membrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages.