What is the catalog number for Anti-Hu CD178 PE?

The catalog number for Anti-Hu CD178 PE is 1P-754-T100.

What sizes are available for Anti-Hu CD178 PE?

Anti-Hu CD178 PE is available in the following size(s): 100 Tests.

Is Anti-Hu CD178 PE in stock?

Anti-Hu CD178 PE is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD178 PE?

Anti-Hu CD178 PE is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD178 PE?

Estimated delivery time for Anti-Hu CD178 PE is approximately 10 business day(s), depending on your location.

Anti-Hu CD178 PE

CD178 / Fas-L (Fas ligand, CD95L), a member of TNF family transmembrane glycoproteins, is responsible for induction of apoptosis in cells containing its receptor CD95 / Fas. The CD178-mediated apoptosis pathway has been implicated in peripheral tolerance, tissue pathology, and maintenance of the immune privileged sites. Defects in this interaction may be related to some cases of systemic lupus erythematosus (SLE) . CD178 was also described as a co-stimulatory receptor for T-cell activation in mice in vivo.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

L5178Y mouse T lymphoma cells expressing recombinant human CD178

Target Antigen

CD178

Clone

NOK-1

Applications

FC (QC tested)

Format

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Ji J, Chen JJ, Braciale VL, Cloyd MW: Apoptosis induced in HIV-1-exposed, resting CD4+ T cells subsequent to signaling through homing receptors is Fas/Fas ligand-mediated. J Leukoc Biol. 2007 Jan;81 (1) :297-305., URL: http://www.ncbi.nlm.nih.gov/pubmed/17056762 , *Kayagaki N, Kawasaki A, Ebata T, Ohmoto H, Ikeda S, Inoue S, Yoshino K, Okumura K, Yagita H: Metalloproteinase-mediated release of human Fas ligand. J Exp Med. 1995 Dec 1;182 (6) :1777-83., URL: http://www.ncbi.nlm.nih.gov/pubmed/7500022 , *Jodo S, Pidiyar VJ, Xiao S, Furusaki A, Sharma R, Koike T, Ju ST: Fas ligand (CD178) cytoplasmic tail is a positive regulator of Fas ligand-mediated cytotoxicity. J Immunol. 2005 Apr 15;174 (8) :4470-4., URL: http://www.ncbi.nlm.nih.gov/pubmed/15814666, *Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O: Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178) . FEBS Lett. 2002 May 22;519 (1-3) :50-8., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=sanzenbacher+r+thiede+b , *Chopin D, Barei-Moniri R, Maillé P, Le Frè re-Belda MA, Muscatelli-Groux B, Merendino N, Lecerf L, Stoppacciaro A, Velotti F: Human urinary bladder transitional cell carcinomas acquire the functional Fas ligand during tumor progression. Am J Pathol. 2003 Apr;162 (4) :1139-49., URL: http://www.ncbi.nlm.nih.gov/pubmed/12651606

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody NOK-1 recognizes an extracellular epitope of CD178 / Fas-L, an approximately 40 kDa transmembrane glycoprotein expressed on neutrophils, monocytes, and activated T and NK cells.