Anti-Hu CD32 PE

*Dutertre CA, Bonnin-Gélizé E, Pulford K, Bourel D, Fridman WH, Teillaud JL: A novel subset of NK cells expressing high levels of inhibitory FcgammaRIIB modulating antibody-dependent function. J Leukoc Biol. 2008 Dec;84 (6) :1511-20, URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=pulford+k+bourel+d , *Os A, Bürgler S, Ribes AP, Funderud A, Wang D, Thompson KM, Tjø nnfjord GE, Bogen B, Munthe LA: Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells. Cell Rep. 2013 Aug 15;4 (3) :566-77., URL: https://www.ncbi.nlm.nih.gov/pubmed/23933259, *Dai X, Jayapal M, Tay HK, Reghunathan R, Lin G, Too CT, Lim YT, Chan SH, Kemeny DM, Floto RA, Smith KG, Melendez AJ, MacAry PA: Differential signal transduction, membrane trafficking, and immune effector functions mediated by FcgammaRI versus FcgammaRIIa. Blood. 2009 Jul 9;114 (2) :318-27., URL: https://pubmed.ncbi.nlm.nih.gov/19420354/, *Vely F, Gruel N, Moncuit J, Cochet O, Rouard H, Dare S, Galon J, Sautes C, Fridman WH, Teillaud JL: A new set of monoclonal antibodies against human Fc gamma RII (CD32) and Fc gamma RIII (CD16) : characterization and use in various assays. Hybridoma. 1997 Dec;16 (6) :519-28., URL: https://pubmed.ncbi.nlm.nih.gov/9455704/, *Boruchov AM, Heller G, Veri MC, Bonvini E, Ravetch JV, Young JW: Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions. J Clin Invest. 2005 Oct;115 (10) :2914-23., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=boruchov+am+heller+g

The mouse monoclonal antibody 3D3 recognizes an extracellular epitope of CD32, a 40 kDa polymorphic transmembrane glycoprotein serving as the low affinity receptor for aggregated IgG. This antibody recognizes CD32 isoforms on B cells of all donors, but on platelets, monocytes, and granulocytes of only some donors (131R variant, but not 131H variant) .