What is the catalog number for Anti-Hu CD23 PE?

The catalog number for Anti-Hu CD23 PE is 1P-689-T100.

What sizes are available for Anti-Hu CD23 PE?

Anti-Hu CD23 PE is available in the following size(s): 100 Tests.

Is Anti-Hu CD23 PE in stock?

Anti-Hu CD23 PE is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD23 PE?

Anti-Hu CD23 PE is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD23 PE?

Estimated delivery time for Anti-Hu CD23 PE is approximately 10 business day(s), depending on your location.

Anti-Hu CD23 PE

CD23 (Fc epsilon RII), the low affinity IgE receptor, is a 45 kDa type II membrane glycoprotein expressed more or less on eosinophils, follicular dendritic cells, Langerhans cells, mature B cells (mainly upon activation), EBV-transformed lymphoblasts, monocytes, and subpopulation of platelets. A soluble form of 37 kDa and other its fragments were also described. CD23 mediates IgE-dependent cytotoxicity by eosinophils and macrophages, and downregulates IgE secretion in response to high levels of IgE, involving release of pro-inflammatory cytokines.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

EBV-transformed human cells

Target Antigen

CD23

Clone

EBVCS-5

Applications

FC (QC tested)

Format

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Byrd JC, O'Brien S, Flinn IW, Kipps TJ, Weiss M, Rai K, Lin TS, Woodworth J, Wynne D, Reid J, Molina A, Leigh B, Harris S: Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia. Clin Cancer Res. 2007 Aug 1;13 (15 Pt 1) :4448-55., URL: https://pubmed.ncbi.nlm.nih.gov/17671129/, *Rumi C, Rutella S, Leone G, Bonini S: Fc-RII/CD23 receptor on circulating human eosinophils. Blood. 1998 Apr 1;91 (7) :2621-2., URL: http://www.ncbi.nlm.nih.gov/pubmed/9516167 , *Ling NR, Stevenson FK, Brown B: Urinary excretion of CD23 antigen in normal individuals and patients with chronic lymphocytic leukaemia (CLL) . Clin Exp Immunol. 1991 Dec;86 (3) :360-6., URL: http://www.ncbi.nlm.nih.gov/pubmed?term=stevenson%20fk%20ling%20nr, *Yamaoka KA, Arock M, Issaly F, Dugas N, Le Goff L, Kolb JP: Granulocyte macrophage colony stimulating factor induces Fc epsilon RII/CD23 expression on normal human polymorphonuclear neutrophils. Int Immunol. 1996 Apr;8 (4) :479-90., URL: http://www.ncbi.nlm.nih.gov/pubmed?term=yamaoka%20ka%20arock%20m , *Belleau JT, Gandhi RK, McPherson HM, Lew DB: Research upregulation of CD23 (FcepsilonRII) expression in human airway smooth muscle cells (huASMC) in response to IL-4, GM-CSF, and IL-4/GM-CSF. Clin Mol Allergy. 2005 May 20;3:6., URL: http://www.ncbi.nlm.nih.gov/pubmed/15907205 , *Quardokus EM, Saunders DC, McDonough E, Hickey JW, Werlein C, Surrette C, Rajbhandari P, Martinez Casals A, Tian H, Lowery L, Neumann EK, Björklund F, Neelakantan TV, Croteau J, Wiblin AE, Fisher J, Livengood AJ, Dowell KG, Silverstein JC, Spraggins JM, Pryhuber GS, Deutsch G, Ginty F, Nolan GP, Melov S, Jonigk D, Caldwell MA, Vlachos IS, Mueller W, Gehlenborg N, Stockwell BR, Lundberg E, Snyder MP, Germain RN, Camarillo JM, Kelleher NL, Börner K, Radtke AJ: Organ mapping antibody panels: a community resource for standardized multiplexed tissue imaging. Nat Methods 2023 Aug;20 (8) :1174-1178. doi: 10.1038/s41592-023-01846-7., URL: https://pubmed.ncbi.nlm.nih.gov/37468619/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody EBVCS-5 recognizes an extracellular epitope located in the stalk region of human low affinity IgE receptor (CD23) between the 37 and 25 kDa cleavage sites.