Anti-Notch1 PE
Notch 1 is a 270-300 kDa transmembrane protein with multiple extracellular growth factor-like repeats, and with an intracellular domain consisting of multiple different domain types. It serves as a receptor for membrane ligands such as DLL1, Jagged 1 (CD339), and Jagged 2, and regulates cell fate decisions. Upon ligand binding the transmembrane form of Notch 1 is repeatedly cleaved to provide approximately 120 kDa Notch intracellular fragment (NICD), which translocates into the nucleus and acts as a part of transcriptional complexes that alter differentiation, proliferation, and apoptosis. The highest level of Notch 1 expression is in bone marrow progenitor cells, brain, lung and thymus.
Product Specifications
Certification
RUO
Negative Species
Rat
Immunogen
GST fusion protein containing cdc10-NCR region of mouse Notch1
Target Antigen
Notch1
Clone
MN1A
Applications
FC-IC (QC tested)
Concentration
0.1 mg/mL
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml. Intracellular staining.
Species
Mouse, Human
CAS Number
9007-83-4
Isotype
Mouse IgG1 kappa
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