Anti-Hu STRO-1 PE
STRO-1 is a cell surface antigen expressed by stromal elements in human bone marrow, identified by monoclonal antibody STRO-1. Approximately 10% of mononuclear cells, greater than 95% of which are nucleated erythroid precursors, are STRO-1 positive, whereas the CFU-GM (colony-forming unit granulocyte-macrophage), BFU-E (erythroid burst) and CFU-Mix (mixed colonies) committed progenitor cells are negative. CFU-F (fibroblast colony-forming cells) are present exclusively in the STRO-1 positive population. When plated under long-term bone marrow culture conditions, STRO-1 positive cells generate adherent cell layers containing multiple stromal cell types, including adipocytes, smooth muscle cells, osteoblasts, chondrocytes, and fibroblastic elements. In combination with glycophorin A, STRO-1 is a useful marker for identification of mesenchymal stem cells. STRO-1 and CD117 are markers for osteosarcoma cells.
Product Specifications
Certification
RUO
Immunogen
Human CD34 positive bone marrow cells
Target Antigen
STRO-1
Clone
STRO-1
Applications
FC (QC tested)
Concentration
0.1 mg/mL
Format
PE
Buffer
Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
References & Citations
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Species
Human, Rabbit, Rat
CAS Number
9007-83-4
Isotype
Mouse IgM lambda
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