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Anti-Hu CD361 PE

CD361, also known as EVI2B (ecotropic viral integration site 2B) or EVDB, is a poorly characterized type I transmembrane protein, expressed from one of three genes embedded in intron 27b of the neurofibromatosis type 1 (NF1) gene. The DNA strand that is transcribed to produce CD361 is the complementary one to the strand encoding NF1. Murine homolog to human CD361 is associated with ecotropic viral insertions, which have been implicated in the expression of murine myeloid leukemias. CD361 has been also reported to be involved in melanocyte and keratinocyte differentiation. However, it is expressed mainly in peripheral blood and bone marrow.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Raji cells

Target Antigen

CD361

Clone

MEM-216

Applications

FC (QC tested)

Format

PE

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Rudolf-Oliveira RCM, Auat M, Cardoso CC, Santos-Pirath IM, Lange BG, Pires-Silva J, Moraes ACR, Dametto GC, Pirolli MM, Colombo MDHP, Santos-Silva MC: Determination of normal expression patterns of CD86, CD210a, CD261, CD262, CD264, CD358, and CD361 in peripheral blood and bone marrow cells by flow cytometry., URL: https://www.ncbi.nlm.nih.gov/pubmed/29274771, *Mouloungui E, Zver T, Roux C, Amiot C: A protocol to isolate and qualify purified human preantral follicles in cases of acute leukemia, for future clinical applications. J Ovarian Res. 2018 Jan 5;11 (1) :4. doi: 10.1186/s13048-017-0376-6., URL: https://www.ncbi.nlm.nih.gov/pubmed/29304838

Other References

*Vyskocil D, Cawthon R, O'Connell P, Xu GF, Stevens J, Culver M, Carey J, White R: The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. Mol Cell Biol. 1991 Feb;11 (2) :906-12., URL: https://www.ncbi.nlm.nih.gov/pubmed/1899288, *Kaufmann D, Gruener S, Braun F, Stark M, Griesser J, Hoffmeyer S, Bartelt B: EVI2B, a gene lying in an intron of the neurofibromatosis type 1 (NF1) gene, is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas. DNA Cell Biol. 1999 May;18 (5) :345-56., URL: https://www.ncbi.nlm.nih.gov/pubmed/10360836

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody MEM-216 recognizes an extracellular epitope of CD361 / EVI2B, almost uncharacterized type I transmembrane protein with broad leukocyte expression, mostly in myeloid and B cells.

Applications Notes

6

Isotype

Mouse IgG1 kappa

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