What is the catalog number for Anti-Hu CD334 PE?

The catalog number for Anti-Hu CD334 PE is 1P-591-T100.

What sizes are available for Anti-Hu CD334 PE?

Anti-Hu CD334 PE is available in the following size(s): 100 Tests.

Is Anti-Hu CD334 PE in stock?

Anti-Hu CD334 PE is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD334 PE?

Anti-Hu CD334 PE is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD334 PE?

Estimated delivery time for Anti-Hu CD334 PE is approximately 10 business day(s), depending on your location.

Anti-Hu CD334 PE

CD334 / FGFR4 (fibroblast growth factor receptor 4), a transmembrane tyrosine kinase, which is expressed in many tissues, such as in lung, kidney, muscle, heart, pancreas, intestine and other, acts as a receptor for several fibroblast growth factors, namely FGF1, FGF2, FGF6, FGF8, and FGF19. Interaction with these growth factors initiates in cell the signaling cascades leading to the mitogenesis and cell differentiation. Presence of CD334 Gly338Arg allele correlates with prognostic parameters in various cancer studies. CD334 plays multiple roles in the organism, including those of muscle regeneration, cholesterol-to-bile acid metabolism, or glucose homeostasis.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

NIH 3T3 cells transfected with full length human CD334

Target Antigen

CD334

Clone

4FR6D3

Applications

FC (QC tested)

Format

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Peterson VM, Castro CM, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R: Ascites analysis by a microfluidic chip allows tumor-cell profiling. Proc Natl Acad Sci U S A. 2013 Dec 17;110 (51) :E4978-86., URL: https://www.ncbi.nlm.nih.gov/pubmed/24297935, *Masuda H, Anwar SS, Bühring HJ, Rao JR, Gargett CE: A novel marker of human endometrial mesenchymal stem-like cells. Cell Transplant. 2012;21 (10) :2201-14., URL: https://pubmed.ncbi.nlm.nih.gov/22469435/

Other References

*Huang X, Yang C, Luo Y, Jin C, Wang F, McKeehan WL: FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes. 2007 Oct;56 (10) :2501-10., URL: https://www.ncbi.nlm.nih.gov/pubmed/17664243?itool, *Zhao P, Caretti G, Mitchell S, McKeehan WL, Boskey AL, Pachman LM, Sartorelli V, Hoffman EP: Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway. J Biol Chem. 2006 Jan 6;281 (1) :429-38., URL: https://www.ncbi.nlm.nih.gov/pubmed/16267055?itool, *Yang YC, Lu ML, Rao JY, Wallerand H, Cai L, Cao W, Pantuck A, Dalbagni G, Reuter V, Figlin RA, Belldegrun A, Cordon-Cardo C, Zhang ZF: Joint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosis. Br J Cancer. 2006 Dec 4;95 (11) :1455-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/17088904?itool, *Bange J, Prechtl D, Cheburkin Y, Specht K, Harbeck N, Schmitt M, Knyazeva T, Müller S, Gärtner S, Sures I, Wang H, Imyanitov E, Häring HU, Knayzev P, Iacobelli S, Höfler H, Ullrich A: Cancer progression and tumor cell motility are associated with the FGFR4 Arg (388) allele. Cancer Res. 2002 Feb 1;62 (3) :840-7., URL: https://www.ncbi.nlm.nih.gov/pubmed/11830541?itool, *Vainikka S, Partanen J, Bellosta P, Coulier F, Birnbaum D, Basilico C, Jaye M, Alitalo K: Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction. EMBO J. 1992 Dec;11 (12) :4273-80., URL: https://www.ncbi.nlm.nih.gov/pubmed/1385111?itool=, *Partanen J, Mäkelä TP, Eerola E, Korhonen J, Hirvonen H, Claesson-Welsh L, Alitalo K: FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J. 1991 Jun;10 (6) :1347-54., URL: https://www.ncbi.nlm.nih.gov/pubmed/1709094?itool=

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 4FR6D3 reacts with an extracellular epitope of CD334, the fibroblast growth factor receptor 4, which is an approximately 88 kDa receptor tyrosine kinase expressed in variety of tissues.