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Anti-Hu CD264 PE

TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4) .

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

TRAIL-R4 (aa 1-210) - hIgGhc fusion protein

Target Antigen

CD264

Clone

TRAIL-R4-01

Applications

FC (QC tested)

Concentration

0.1 mg/mL

Format

PE

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Other References

*Deligezer U, Dalay N: Expression of the TRAIL Receptors in Blood Mononuclear Cells in Leukemia. Pathol Oncol Res. 2007;13 (4) :290-4., URL: https://www.ncbi.nlm.nih.gov/pubmed/18158563?ordin, *Falschlehner C, Emmerich CH, Gerlach B, Walczak H: TRAIL signalling: decisions between life and death. Int J Biochem Cell Biol. 2007;39 (7-8) :1462-75., URL: https://www.ncbi.nlm.nih.gov/pubmed/17403612?ordin, *Mérino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O: Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol. 2006 Oct;26 (19) :7046-55., URL: https://www.ncbi.nlm.nih.gov/pubmed/16980609?ordin, *Sanlioglu AD, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S. Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC Cancer. 2005 May 25;5 (1) :54., URL: https://www.ncbi.nlm.nih.gov/pubmed/15916713?ordin, *Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK: Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc Natl Acad Sci U S A. 2005 Dec 13;102 (50) :18099-104., URL: https://www.ncbi.nlm.nih.gov/pubmed/16319225?ordin

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The antibody TRAIL-R4-01 reacts with an extracellular epitope of TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.

Applications Notes

Flow cytometry: Recommended dilution: 1-4 µg/ml

Isotype

Mouse IgG1

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