What is the catalog number for Anti-Hu CD36 PE?

The catalog number for Anti-Hu CD36 PE is 1P-451-T100.

What sizes are available for Anti-Hu CD36 PE?

Anti-Hu CD36 PE is available in the following size(s): 100 Tests.

Is Anti-Hu CD36 PE in stock?

Anti-Hu CD36 PE is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD36 PE?

Anti-Hu CD36 PE is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD36 PE?

Estimated delivery time for Anti-Hu CD36 PE is approximately 10 business day(s), depending on your location.

Anti-Hu CD36 PE

CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and it is rapidly induced on follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similarly to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Platelets

Target Antigen

CD36

Clone

TR9

Applications

FC (QC tested)

Format

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Zamora C, Cantó E, Nieto JC, Ortiz MA, Diaz-Torné C, Diaz-Lopez C, Llobet JM, Juarez C, Vidal S: Functional consequences of platelet binding to T lymphocytes in inflammation. J Leukoc Biol. 2013 Sep;94 (3) :521-9. , URL: https://www.ncbi.nlm.nih.gov/pubmed/23801652, *Bertrand G, Renac V, Lefaix MC, Nivet C, Trudel E, Richard L: Neonatal Intracranial Hemorrhage with a Dramatic Outcome Due to Maternal Anti CD36 Antibodies. Reports 2019, 2 (1), 7; doi:10.3390/reports2010007 , URL: https://www.mdpi.com/2571-841X/2/1/7, *Berre S, Gaudin R, Cunha de Alencar B, Desdouits M, Chabaud M, Naffakh N, Rabaza-Gairi M, Gobert FX, Jouve M, Benaroch P: CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells. J Exp Med. 2013 Nov 18;210 (12) :2523-38., URL: https://www.ncbi.nlm.nih.gov/pubmed/24145510

Other References

*Gaillard D, Laugerette F, Darcel N, El-Yassimi A, Passilly-Degrace P, Hichami A, Akhtar Khan N, Montmayeur JP, Besnard P: The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J. 2007 Dec 27, URL: https://www.ncbi.nlm.nih.gov/pubmed/18162488?ordin, *van Oort MM, van Doorn JM, Bonen A, Glatz JF, van der Horst DJ, Rodenburg KW, Luiken JJ: Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4. Biochim Biophys Acta. 2007 Dec 15, URL: https://www.ncbi.nlm.nih.gov/pubmed/18167317?ordin, *Won WJ, Bachmann MF, Kearney JF: CD36 Is Differentially Expressed on B Cell Subsets during Development and in Responses to Antigen. J Immunol. 2008 Jan 1;180 (1) :230-7., URL: https://www.ncbi.nlm.nih.gov/pubmed/18097024?ordin

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The antibody TR9 reacts with an extracellular epitope of CD36 (GPIIIb), a 85 kDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. The antibody TR9 cross-blocks binding of FITC-labeled standard antibody OKM5. Anti-CD36 antibodies inhibit adhesive functions (e.g. adherence of infected erythrocytes to target cells) .