What is the catalog number for Anti-Hu CD54 PE?

The catalog number for Anti-Hu CD54 PE is 1P-429-T100.

What sizes are available for Anti-Hu CD54 PE?

Anti-Hu CD54 PE is available in the following size(s): 100 Tests.

Is Anti-Hu CD54 PE in stock?

Anti-Hu CD54 PE is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD54 PE?

Anti-Hu CD54 PE is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD54 PE?

Estimated delivery time for Anti-Hu CD54 PE is approximately 10 business day(s), depending on your location.

Anti-Hu CD54 PE

CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1) . The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Raji cells and spleen cells fused with NS1 cells

Target Antigen

CD54

Clone

1H4

Applications

FC (QC tested)

Format

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Williams DT, Chaudhry Y, Goodfellow IG, Lea S, Evans DJ: Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites. J Gen Virol. 2004 Mar;85 (Pt 3) :731-8. , URL: https://www.ncbi.nlm.nih.gov/pubmed/14993659?dopt=

Other References

*Boyd AW, Wawryk SO, Burns GF, Fecondo JV: Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cell contact-mediated immune mechanisms. Proc Natl Acad Sci U S A. 1988 May;85 (9) :3095-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/3362863?dopt=A, *Boyd AW, Dunn SM, Fecondo JV, Culvenor JG, Duhrsen U, Burns GF, Wawryk SO: Regulation of expression of a human intercellular adhesion molecule (ICAM-1) during lymphohematopoietic differentiation. Blood. 1989 May 15;73 (7) :1896-903., URL: https://www.ncbi.nlm.nih.gov/pubmed/2469503?dopt=A, *Springer TA: Adhesion receptors of the immune system. Nature. 1990 Aug 2;346 (6283) :425-34., URL: https://www.ncbi.nlm.nih.gov/pubmed/1974032?dopt=A, *Ockenhouse CF, Betageri R, Springer TA, Staunton DE: Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus. Cell. 1992 Jan 10;68 (1) :63-9. Erratum in: Cell 1992 Mar 6;68 (5) :following 994., URL: https://www.ncbi.nlm.nih.gov/pubmed/1346257?dopt=A

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The antibody 1H4 recognizes an extracellular epitope of CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus) expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells; the expression of CD54 is upregulated by activation.