What is the catalog number for Anti-Hu CD273 PE?

The catalog number for Anti-Hu CD273 PE is 1P-178-T100.

What sizes are available for Anti-Hu CD273 PE?

Anti-Hu CD273 PE is available in the following size(s): 100 Tests.

Is Anti-Hu CD273 PE in stock?

Anti-Hu CD273 PE is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD273 PE?

Anti-Hu CD273 PE is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD273 PE?

Estimated delivery time for Anti-Hu CD273 PE is approximately 10 business day(s), depending on your location.

Anti-Hu CD273 PE

CD273 / PD-L2 (programmed death ligand-1), also known as B7-DC, is a member of the B7 family of regulatory proteins. It costimulates the proliferation of T cells, and mediates IFN gamma production. Ligation of CD273 on dendritic cells enhances dendritic cell activation and T cell responses. When interacting with CD279, it can act as a coinhibitor of the T cell function. CD273 expression is a useful marker to distinguish primary mediastinal B cell lymphoma from other diffuse large B cell lymphomas.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Human CD273 cDNA

Target Antigen

CD273

Clone

24F.10C12

Applications

FC (QC tested)

Format

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, O'Donnell E, Chapuy B, Takeyama K, Neuberg D, Golub TR, Kutok JL, Shipp MA: Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010 Oct 28;116 (17) :3268-77., URL: http://www.ncbi.nlm.nih.gov/pubmed/20628145, *Rodríguez-García M, Porichis F, de Jong OG, Levi K, Diefenbach TJ, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DG: Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. J Leukoc Biol. 2011 Apr;89 (4) :507-15., URL: https://pubmed.ncbi.nlm.nih.gov/21097698/, *Semnani RT, Mahapatra L, Moore V, Sanprasert V, Nutman TB: Functional and phenotypic characteristics of alternative activation induced in human monocytes by interleukin-4 or the parasitic nematode Brugia malayi. Infect Immun. 2011 Oct;79 (10) :3957-65., URL: http://www.ncbi.nlm.nih.gov/pubmed/21788379

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 24F.10C12 recognizes an extracellular epitope of CD273 / PD-L2 (also known as B7-DC), a 25 kDa type I transmembrane protein expressed by dendritic cells, activated monocytes and T cells, heart, first trimester placenta, lung and liver, as well as in Hodgkin´s lymphoma cells and primary mediastinal B cell lymphoma (PMBL) .