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Anti-Hu CD85g PE

CD85g / ILT7 (immunoglobulin-like transcript 7) is a cell surface protein that is expressed on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response, such as the TLR-induced interferon production. It associates with gamma subunit of the high-affinity IgE receptor to form a receptor complex which transduces the signal through ITAM-associated downstream molecules. Expression of CD85g is downregulated by interleukin 3.

Product Specifications

Certification

RUO

Target Antigen

CD85g

Clone

17G10.2

Applications

FC (QC tested)

Format

PE

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Cao W, Rosen DB, Ito T, Bover L, Bao M, Watanabe G, Yao Z, Zhang L, Lanier LL, Liu YJ: Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. J Exp Med. 2006 Jun 12;203 (6) :1399-405., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=cao+w+rosen+db+ito+t+bover+l, *Tavano B, Galao RP, Graham DR, Neil SJ, Aquino VN, Fuchs D, Boasso A: Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes. J Immunol. 2013 Mar 15;190 (6) :2622-30., URL: https://pubmed.ncbi.nlm.nih.gov/23401591/, *Tavano B, Boasso A: Effect of immunoglobin-like transcript 7 cross-linking on plasmacytoid dendritic cells differentiation into antigen-presenting cells. PLoS One. 2014 Feb 19;9 (2) :e89414., URL: http://www.ncbi.nlm.nih.gov/pubmed/24586760

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 17G10.2 recognizes an extracellular epitope of CD85g / ILT7, a member of leukocyte immunoglobulin-like receptor family expressed on plasmacytoid dendritic cells, but not on myeloid dendritic cells and other peripheral blood leukocytes.

Applications Notes

6

Species

Human

CAS Number

9007-83-4

Isotype

Mouse IgG1 kappa

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