What is the catalog number for Anti-Hu CD170 PE?

The catalog number for Anti-Hu CD170 PE is 1P-156-T100.

What sizes are available for Anti-Hu CD170 PE?

Anti-Hu CD170 PE is available in the following size(s): 100 Tests.

Is Anti-Hu CD170 PE in stock?

Anti-Hu CD170 PE is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD170 PE?

Anti-Hu CD170 PE is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD170 PE?

Estimated delivery time for Anti-Hu CD170 PE is approximately 10 business day(s), depending on your location.

Anti-Hu CD170 PE

CD170, also known as Siglec 5 (sialic acid binding Ig-like lectin 5) is a type 1 transmembrane glycoprotein containing two cytoplasmic immunoreceptor tyrosine inhibitory motifs (ITIMs) . CD170 forms homodimers and functions as an inhibitory receptor able to downregulate cell activation. It binds to alpha2,3- and alpha2,6-linked sialic acid ligands, e.g. on glycophorin A (CD235a) . Aberrant expression of CD170 by CD34+ progenitor cells can be observed in case of acute myeloid leukemias.

Product Specifications

Certification

RUO

Reactivity

Non-human primates, Human

Immunogen

Fusion protein composed of human CD170 extracellular domain and Fc region of human IgG1

Target Antigen

CD170

Clone

1A5

Applications

FC (QC tested)

Format

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Avril T, Freeman SD, Attrill H, Clarke RG, Crocker PR: Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J Biol Chem. 2005 May 20;280 (20) :19843-51., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=avril+t+freeman+sd, *Yokoi H, Myers A, Matsumoto K, Crocker PR, Saito H, Bochner BS: Alteration and acquisition of Siglecs during in vitro maturation of CD34+ progenitors into human mast cells. Allergy. 2006 Jun;61 (6) :769-76., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=yokoi+h+myers+a , *Angata T, Hayakawa T, Yamanaka M, Varki A, Nakamura M: Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. FASEB J. 2006 Oct;20 (12) :1964-73., URL: http://www.ncbi.nlm.nih.gov/pubmed/17012248 , *Schuster P, Donhauser N, Pritschet K, Ries M, Haupt S, Kittan NA, Korn K, Schmidt B: Co-ordinated regulation of plasmacytoid dendritic cell surface receptors upon stimulation with herpes simplex virus type 1. Immunology. 2010 Feb;129 (2) :234-47., URL: http://www.ncbi.nlm.nih.gov/pubmed/19824924

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 1A5 recognizes an extracellular epitope of CD170 (Siglec-5, sialic acid binding Ig-like lectin 5), a transmembrane glycoprotein expressed strongly by neutrophils, macrophages activated during infections, monocytes, and dendritic cells. As in case with other anti-CD170 antibodies, this antibody crossreacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.